Goal page
Peptides studied for gut inflammation
One peptide in our data has been studied for gut inflammation: KPV. All of it is in mice or in cells. There are no human studies of KPV for anything, and the FDA states it found no human exposure data for KPV at all. This is the thinnest evidence on the site and it is ranked last for that reason.
Byline: PeptideGauge Editors. Sources checked 2026-08-24. Every study below links to its PubMed record. We do not publish amounts or schedules.
None of these is an approved medicine. Every peptide on this page is sold as a research chemical, none is approved by the FDA for any use, and for most of them the human safety record is a handful of people or nobody at all. This page tells you what has been studied. It does not tell you to use anything, how much, or how often. That belongs with a licensed doctor. Why we draw that line.
How we ranked these, before you see the ranking
The order below is arithmetic, not opinion. Each peptide gets four scores out of 100, and they are added up with fixed weights. Every score on this page is shown, so you can check the sum yourself or decide the weights are wrong.
- Evidence strength, 40 percent. The strongest single study we found for this goal. A randomised trial in people scores 100, a systematic review 75, a small human study 50, a review article 30, an animal study 25, cells in a dish 10.
- Human data, 25 percent. How many of the studies for this goal were done in people. None scores 0, one scores 40, two 60, three 80, four or more 100.
- Safety record, 20 percent. Some human safety reporting scores 70. Animal safety data only scores 35. No human safety data found scores 10. Nothing scores above 70, because nothing here has long term safety data in people.
- Regulatory clarity, 15 percent. An FDA approved drug scores 100. A substance on the FDA list of compounding nominations that were withdrawn scores 25. If the FDA also says it found no human exposure data, it scores 10.
Read the evidence score carefully. It measures how strong the study was, not how well the peptide worked. A well run trial that found nothing scores 100 here. The finding column tells you what it actually found, and on this site a well run trial that found nothing is the most useful kind of result there is.
Full rules and any changes to them: How we check.
The ranking
Sorted by total score. Every number that went into the total is in the row.
| Score | Peptide | Evidence 40% | Human data 25% | Safety 20% | Regulatory 15% | Strongest study we found |
|---|---|---|---|---|---|---|
| 14#1 | KPV Four mouse studies of bowel inflammation. Nothing in people. | 25evidence | 0human data | 10safety | 10regulatory | Animals In two mouse models of bowel inflammation, KPV reduced colitis severity. |
What counts as this goal: Studies about inflammation of the bowel, in animals or in cells.
How to read the study tags
Cells in a dish means it never touched a living animal. Animals means mice or rats, usually. Small human study means a handful of people with no comparison group. Human trial means people were randomly split into treated and untreated groups, which is the only kind that can show an effect is real. Review and Systematic review sum up other studies. The full rule is on How we check.
KPV
A three amino acid piece of a natural hormone called alpha-MSH.
Score for this goal: 14 out of 100. The math: (25 x 40 + 0 x 25 + 10 x 20 + 10 x 15) divided by 100 = 14.
Safety, before the studies
No human safety data found. We found no human study of KPV at all. The FDA states it has found no human exposure data for KPV.
On the FDA withdrawn list, and the FDA says it found no human exposure data. Nothing on this page is an approved drug. We do not publish amounts or schedules for any of it.
What has been studied for gut inflammation
| Who or what was studied | What was found, and the catch | Source |
|---|---|---|
| Animals | In two mouse models of bowel inflammation, KPV reduced colitis severity. Limit: Mice only; paper notes KPV is hard to deliver and unstable. | Kannengiesser 2008 PMID 18092346 |
| Animals | A gut transporter moved KPV into intestinal cells, and that uptake went with less inflammation. Limit: Mice only. | Dalmasso 2008 PMID 18061177 |
| Animals | KPV packed into nanoparticles eased mouse colitis better than KPV alone. Limit: Results may owe as much to the nanoparticle as to KPV. | Xiao 2017 PMID 28143741 |
| Animals | KPV reduced inflammatory cell build-up in mice about as well as the full hormone. Limit: Mechanism study, not a disease outcome. | Getting 2003 PMID 12750433 |
What is missing
- No human study of KPV exists for any use, let alone this one.
- The FDA says it found no human exposure data for KPV.
- One of the mouse results came from KPV packed into nanoparticles, so the nanoparticle may deserve some of the credit.
- The 2008 mouse paper says plainly that KPV is unstable and hard to deliver.
What this page does not cover, and why
BPC-157 is often sold for gut problems. The studies we have read for BPC-157 are about tendon, ligament, muscle and bone, so it is not ranked on this page. If we find gut studies we will add it and say so in the fixes log.
Sources
- Dalmasso (2008). PMID 18061177
- Getting (2003). PMID 12750433
- Kannengiesser (2008). PMID 18092346
- Xiao (2017). PMID 28143741
FDA list of bulk drug substances nominated for compounding and withdrawn, last checked 2026-08-24: fda.gov. Every claim above is also on our evidence table.
Other goals
Injury recovery
Studies about healing damaged tendon, ligament, muscle, bone or joint tissue after an injury.
See the rankingWound healing
Studies about closing skin wounds, burns, and ulcers that will not heal.
See the rankingSkin and aging
Studies about skin appearance, collagen, scalp and hair, in people or in human skin cells.
See the rankingMixing a vial? Do the math with the calculator.
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